The last game I ran was a d20 Modern, CoC d20 and Monte Cook's World of Darkness hybrid. The PC's were a team of ghost hunters, just like on TV, that ended up investigating an abandoned psychiatric hospital that is infested with ghost, demons and other ghoulies. Sure it isn't the most original of ideas, but it was a lot of fun and went very well.
My player's consisted of one long time player, his daughter, my daughter, one of my regular teen players and his girlfriend. It was the girlfriend's first time playing and I am happy to report that not only did everyone have a good time, but I think I ran a damn fine game. In the past few years I've been really fortunate, depending on your perspective, because I have had a lot of players that have never played a table top rpg before. Considering that we don't have a FLGS I think it is pretty great that I've seen 8 new players in the past few years. Not just new to my table but new to the entire experience. That's pretty cool.
Despite many years of GMing I continue to learn about not only the experience, but myself. Every "great" game I've ran for the past few years has been non-fantasy. Sure I love my 3e/Pathfinder, I like 4e and I'm even fond of several other fantasy games, but I'm just not having fun running fantasy and haven't been for quite a while. Running a fantasy game feels like a chore, like work. I'm just burned out on fantasy and don't even enjoy reading or watching S&W fantasy at the moment.
All of the games that get me excited, make me want to play are all non-fantasy. I have quiet a few games that I am really excited about playing like Mutant Epoch, Mutants & Masterminds 3e/DC Adventures, Hollow Earth Expedition, Buffy tVS, and all of my d20 Modern/CoC/MCWoD books.
I've got a game coming up and this time I'm considering running either M&M3e or Buffy. I'm wanting to try my hand at running a supers game, so I'm leaning heavily towards M&M. Before we go on winter hiatus I'm going to try to run a post-apocalyptic game. Assuming the the players are okay with it. Now that they've decided to leave the "I only play fantasy" player out of the group for a bit everyone else is eager to try something new. That's fine by me.